Can meal replacements help overweight diabetic patients lose weight effectively and keep it off? That was the question that Lawrence J. Cheskin and colleagues from the John Hopkins Bloomberg School of Public Health (Baltimore, Maryland) tried to answer in their recent study “Efficacy of Meal Replacements versus a Standard Food-Based Diet for Weight Loss in Type 2 Diabetes,” published in The Diabetes Educator.
Increased Rates of Type 2 Diabetes
High numbers of Americans are clinically obese with the number increasing each year. Approximately 66% of adults in the U.S. are overweight with about half of that number designated as obese. The higher obesity rate correlates with an increase in type 2 diabetes. The link between type 2 diabetics and obesity is clear with 70% of that population being overweight and 33% labeled obese. Over 18 million people in the U.S. currently experience type 2 diabetes with the number expected to go up dramatically. By 2050 the estimated number of people with type 2 diabetes will rise by 165% [1].
Weight loss is recognized as an effective method to manage or prevent type 2 diabetes. When patients lose even 2% of their body weight, they can see positive indicators in many health markers. Those who succeed in their efforts to lose weight most likely account for lower numbers in mortality rates for type 2 diabetics. However, achieving weight loss for this group is difficult. Most obese people find that losing weight is a challenge, but it is even more difficult for those with type 2 diabetes [2].
Are Food Replacements a Viable Alternative for Weight Loss?
The main objective in Cheskin’s study was to compare weight loss success and specific results in two groups. The groups were taken from 126 adult screened volunteers. One group followed a standard food-based diet while the other group used a food replacement supplement.
Groups included men and women from 18 to 70 years old with BMI numbers ranging from 25-40. Overweight and obesity rates were determined by body mass index. A BMI of 25 was considered overweight while a BMI of 32.2 represented obese. One purpose of the study was to see if either method could produce results of at least a 5% weight loss in obese patients with type 2 diabetes. The possibility of using a food replacement supplement as a viable tool to manage type 2 diabetes was also a focus.
The two groups involved in the study followed one of two diets. One group followed a standard diet using foods recommended by the American Diabetes Association (ADA). The other participants were prescribed Medifast Plus for Diabetics meal replacement for their portion-controlled diet. This food supplement contains soy-based products low in sugar with a low glycemic index [3]. Both diets had similar calorie content and both groups experienced a 25% calorie reduction in their diet. Each diet offered 45-50% carbohydrates, 25-30% fat and 15-25% protein.
What Were The Results Of The Study?
Following 34 weeks of weight loss, the standard diet group stayed on the same diet plan with the same guidelines for an additional 52 weeks. The food replacement group, however, broke into two groups. Each used the food replacement diet and the standard food diet alternating after 26 weeks. The nutritional value in the diet prescribed to both groups was similar. The standard diet group got all their allotted calories from whole foods using choices on the ADA list. The food supplements participants got about 50-60% of calories allowed through the Medifast meal replacement.
BMI
After 34 weeks, results showed better BMI numbers for both groups. However, the BMI numbers in the food replacement group were significantly lower than the standard diet group. Weight loss for the food replacement group was 6.84% compared to the standard diet number of 3.70%. In addition, food replacement participants dropped 5% of their starting weight. Fasting blood glucose and triglycerides also improved for the group using the supplement while the other group showed no significant change. Cholesterol numbers improved for both groups and ranged in lowering percentages from 2.5-4.4%.
HbA1c
The levels of hemoglobin HbA1c reveal how effectively glucose is controlled in the body. Glucose in diabetic patients is considered under adequate control if HbA1c is less than 7%. At the 34-week mark, almost 3 out of 4 food-replacement participants presented HbA1c below 7%. Specifically, the Medifast supplement group achieved an average of 74.2% of members gaining acceptable glucose control. The other group did not have a significant change in their HbA1c. In fact, the standard-diet group numbers were lower at 35.3%.
Blood Pressure
At 34 weeks systolic and diastolic blood pressure showed much lower numbers for both groups.
Waist and hip measurements also revealed improvement. The food replacement group reduced waist circumference by 6.5cm and hips by 4.1cm. The standard diet participants decreased waist size by only 4.1cm and hips by 1.6cm.
Psycometrics
The area of psychometrics measuring levels of depression, appetite, satisfaction with diet, or a sense of being deprived due to diet noted no significant difference between the groups.
Participants Reduced Dependence on Medications
After the 34-week weight loss phase, retention of people in the study was much better for the food replacement group. They retained 57% of participants compared to 29% in the standard food group. The food replacement members also noted several people who were able to reduce a need for medication to control the disease. In contrast, the standard-diet group’s medication needs remained the same.
Study Supports Potential of Supplement Use
As previously noted, successful weight loss is difficult for obese people with type 2 diabetes. It’s important to note that success rates are often poor. However, meal replacements show that the features of convenience, built-in portion control and easy use may prove beneficial to this group [4]. More members of the food supplement group remained in the study than the people eating a standard diet. That could indicate future potential in using food supplements in some of the so-called best rated weight loss plans for type 2 diabetes.
Several important achievements occurred in the study for participants using a food supplement diet. Li Z. has reported similar findings to support meal replacements as a weight loss tool for type 2 diabetes patients [5]. Members of the food replacement groups achieved an important goal of reducing the need for some medications. Taking less prescription medications is a positive indicator. Most importantly, those succeeding in losing weight with the food supplement diet reported an overall improvement in the quality of their lives.
The above results were presented in the annual meeting of American Diabetes Association. It is important to note that Medifast, the company that makes the meal replacement products that where used in this study, supported the project with its own grant. However, the authors reported no financial interest in the products mentioned.
Matt Denos
Having a medical science background Matt Denos, PhD, follows the current research in the field of diet and weight loss and enjoys writing relevant articles. In his website he offers Medifast diet coupon code discounts, a diet plan for diabetics.
References
1. Boyle, JP et al, Projection of diabetes burden through 2050; impact of changing demography and disease prevalence in U.S. diabetes care, 2001.
2. Hensrudd DD, Dietary treatment and long-term weight loss and maintenance in type 2 diabetes, 2001.
3. Noakes M, Foster PR, Keogh JB, Clifton PM, Meal replacements are as effective as structured weight-loss diets for treating obesity in adults with features of metabolic syndrome, 2004.
4. Pi-Sunyer FX, et al, Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes, Diabetes Care, 1999.
5. Li Z, et al, Long-term efficacy of soy-based meal replacement vs. an individualized diet plan in obese type 2 participants; relative effects on weight loss, metabolic parameters, and C-reactive protein, 2005.